When Cryptosporidium 137 arrives on Earth, Huffman has won the election against Nixon (historically, John F. Kennedy won this election). Most of the Americans in Santa Modesta see him as sleazy and crooked (except for some women). The Military (particularly Armquist) dislike him because he is practically a puppet for Silhouette and her Majestic agency.
After Armquist's death in Union Town, Huffman makes a public speech in front of the Capitol Building, where he is assassinated by Crypto. If Crypto fails to assassinate him within the time limit, the papers will call President Huffman loco because of his "confused speech". His brain was later used to build the Roboprez, a giant robot controlled by Silhouette. It was destroyed by Crypto's Saucer.
Crypto later uses Huffman's body to masquerade as the President, yet for some reason, many people still recognize him as the President even when not in disguise.
- If Cortex Scan is used on him, Huffman is seen as somewhat sadistic, having witnessed the murder of Crypto 136, he comments it was good to see the look on his face and listen to him squeal "like a pig".
- Even if Huffman is disintegrated, Silhouette will still get his brain for the Roboprez.