The casino plays an important role in the early stages of Path of the Furon. It's run by the Molinari Brothers, who have sent a spy to gather information on the Space Dust. Crypto infiltrates the mob's casino and destroys the interior, driving out the customers, causing the mob to go to war with him. He defeats the mob, destroys their profits and takes control of Las Paradiso.
After Crypto defeats the attacking Nexosporidium Warriors, Pox orders Crypto to destroy all of Paradiso, including the Palazzo. Although it is destroyed after the main missions in Paradiso, it still stands if you return.
- The Palazzo is based on Caesar's Palace in Vegas. Although is based on the second building behind it.
- It's named after Nero, one of the more famously insane Roman Emperors.