E. Coli was Orthopox's ex-lover and daughter of Emperor Meningitis.


When Pox worked for Emperor Meningitis as part of a summer job, his daughter, E.Coli and Pox became romantically involved. But the truth was she was just using him to make her father angry, who bribed her with a personal transportation device. Pox was promptly dumped by her afterwards.


  • Pox thinks all rich women are "vipers" because of his relationship with E.Coli, like Patty Wurst.
  • Pox acknowledges that she was an evil genius like him.
  • E. Coli's name is based off of the harmful bacteria of the same name.