The following information is based on Big Willy Unleashed and should not be considered as canon.

E. Coli was Orthopox's ex-lover and daughter of Emperor Meningitis.


When Pox worked for Emperor Meningitis as part of a summer job, his daughter, E.Coli and Pox became romantically involved. But the truth was she was just using him to make her father angry, who bribed her with a personal transportation device. Pox was promptly dumped by her afterwards.


  • Pox thinks all rich women are "vipers" because of his relationship with E.Coli, like Patty Wurst.
  • Pox acknowledges that she was an evil genius like him.
  • E. Coli's name is based off of the harmful bacteria of the same name.

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.