|The following information is based on Big Willy Unleashed and should not be considered as canon.|
When Pox worked for Emperor Meningitis as part of a summer job, his daughter, E.Coli and Pox became romantically involved. But the truth was she was just using him to make her father angry, who bribed her with a personal transportation device. Pox was promptly dumped by her afterwards.
- Pox thinks all rich women are "vipers" because of his relationship with E.Coli, like Patty Wurst.
- Pox acknowledges that she was an evil genius like him.
- E. Coli's name is based off of the harmful bacteria of the same name.