Don Straniero is the leader of the Las Paradiso Mob and was Mikey and Vinnie Molinari's superior.
Pox assigns Crypto to go disguise himself to cut the Molinaris off from "the family", in retaliation for the Molinari Brothers sending their mobsters to attack the Space Dust earlier. Crypto finds him by by using Abducto Beam on his limo and bringing him to a remote area so that Crypto could Body Snatch him easier. After chatting with the other members of the Las Paradiso Mob, the Mob agrees with the Don, and the Molinari Brothers are successfully cut off from the Mob.
- He is a parody of Vito Corleone.
- He is one of the few enemy leaders in the Destroy All Humans! series who is not killed.
- He is also one of the few enemy leaders to not have played a very major role in game's story.