Blind Willie Syphilis is a Furon blues singer.
In a Cult of Arkvoodle in Albion, Crypto brings him up with Canal Side Mob and says they're not cool enough if they hadn't heard of him. The Canal Side Mob leader then lies and says that he "has" heard of him. Crypto later gets a collection of his music on Gastro's music datacore when he has to go retrieve it and kill the Pirate DJ.
- His name is an obvious reference to "Blind Willie Johnson", a real-life gospel blues singer and guitarist.
- Destroy All Humans! 2 (mentioned only)