While the Furons were stuck harvesting DNA on Earth, Pox has kept busy by dabbling in human business affairs. Pox has needed a way to dispose of the human corpses of whom Crypto sucks out the brain stems (he always thought they just faded away when he goes around the corner). He gets the idea to start a fast-food chain called "Big Willy's" in which he sells the meat to grind into hotdogs from inside their warehouses, their main food product.
The chain is made up of a total of 500 restaurants and counting. Pox has mentioned that every single one has a Big Willy mech out front, disguised as a harmless ornament to make teenagers (its best customers) feel welcome. The franchise also owns the Romance-A-Liner cruise ship that the Furons used to sneak into Fantasy Atoll once. Pox mentioned that the USDA works with him on their cannibalistic scheme, only caring that they use "American grown meat."
Big Willy's hotdogs and fries are fried in motor oil, and their smoothies contain leaded petroleum so whoever drinks it would lose all of their taste buds, which would make their hotdogs even more digestible. An unorthodox, if not bizarre, method for fast-food making. There have been some difficulties because of the infamous oil shortages of the 1970's.
It's main competitor is Kluckin's Kitchen run by Colonel Kluckin. After the defeat of Colonel Kluckin, Pox gave up on the fast food business and sold the chain to an unknown party. The profits of which were used to start the Space Dust casino in Las Paradiso. It may be possible that Big Willy's is still using human meat, because the Furons still need to keep the bodies off of the street, and their mission secret.
- In the game, Big Willy Unleashed, it is the focus point for the restaurant. Cryptosporidium enforces the restaurant chain throughout the whole game.
- In Path of the Furon, the restaurant can be found beside the Sultan Casino Hotel in Las Paradiso where it features the prices of each meal and reveals that burgers have been added to the menu.
- A recurring joke in the game is that people (mostly Pox) talk about their "big willy", which irritates Crypto endlessly because it sounds wrong.