In Destroy All Humans! Pox assigns Crypto to dispose of General Armquist and the Army base in Area 42 as whole with a weapon capable of destroying the entire area. Fortunately, an experimental Atomic Bomb is nearby. Crypto then hypnotizes the truck driver into driving the armed truck to the Air Force base in Area 42. Crypto then carefully escorts the truck all the way there. Their scientists try to disarm the bomb, but Crypto destroys all who come near it. He then makes his escape.
Moments after Crypto leaves, the bomb ignites. The explosion destroyed the airfield at Area 42, leaving only the main Military base.
- It is not only the most powerful weapon in the game it is also the most powerful game in the series period.
- It also the most powerful man-made weapon.
- It is one of the few land vehicles that Crypto cannot use PK on, due to how heavy it is.